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TrueMass Lipomic Panel quantifies up to 450 individual metabolites involved in structural and energetic lipid metabolism. The concentration and complete fatty acid composition of triglyceride, cholesterol ester, diglyceride, free fatty acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, cardiolipin and lysophosphatidylcholine are determined producing a high resolution profile of basic lipid metabolism. TrueMass Lipomic Panel quantifies the lipid metabolites from almost any biological matrix including plasma, serum, tissues and cells. This platform is useful in profiling all diseases as structural and energetic lipids are central components of metabolism and integrated into virtually every biological process in the body.

This preparative step generates VLDL, LDL and HDL fractions for further analysis by TrueMass panels. Preparative lipoprotein separation combined with other TrueMass platforms provides a high-resolution of the biochemical processes involved in the assembly and metabolism of lipoproteins.

TrueMass Inflammatory Lipid Panel generates quantitative data on a broad range of eicosanoids from the cyclooxygenase, lipoxygenase and P450 pathways of inflammatory lipid mediator synthesis. Eicosanoids are the central inflammatory lipid compounds of metabolism and are involved in immune response, vasodilation and constriction, macrophage recruitment, blood clotting, inflammation, pain and swelling. A central role for inflammation is emerging in metabolic disorders, cardiovascular disease and of course inflammatory and auto-immune disorders.

TrueMass Fatty Acid Oxidation Panel profiles short- and long-chain acylcarnitines, intermediate products of mitochondrial β-oxidation—or fat burning—as well as free carnitine and its biosynthetic precursors to provide useful indices of energy balance, exercise intensity and fat utilization. Acylcarnitines provide valuable information for the study, diagnosis and understanding of metabolic disorders, myopathies, congestive heart failure and end stage renal disease.

TrueMass Cholesterol Metabolism Panel provides quantitative data on intermediates of sterol biosynthesis, sterol absorption and bile acid metabolism. Sterol intermediates and bile acids provide insight into processes involved in cholesterol synthesis, absorption and excretion, and are central to investigating cardiovascular and other disorders.

Lipomic Surveyor reveals changes in metabolic status due to drug treatment or other intervention. It is a flexible and easy-to-use graphical interface for visualizing and interpreting results from TrueMass and other Lipomics assays. The Lipomic Surveyor organizes metabolites by families of fatty acid pathways in an interactive heat map using user specified parameters.

Results from TrueMass analysis are presented in an Insight pathway map. Lipomics works with partners to develop custom Signature algorithms for the development of biomarkers with improved sensitivity, specificity, translational utility and biological relevance.