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Metabolomics Connects Genome to Phenotype

Metabolomics Connects Genome to Phenotype

Understanding phenotypes is the central need for enabling research and medical advances. The exploration of gene function and the use of genomics tools have been a focal-point for unraveling phenotypes for the last 2 decades. But, while these genomic tools have provided many important insights and discoveries a staggeringly complex picture has also emerged. Deciphering the meaningful biological signal form noise amongst all of this complexity is a persistent challenge.

Since metabolites are regarded as an intermediate phenotype, metabolomics has emerged as an ideal way to bridge the genotype-phenotype relationship. However, there are critical considerations to successful implementation of metabolomics; platforms must be highly stable, scalable and able to capture a meaningfully broad swath of the metabolites within a biological sample.